CKB1 — Magnaporthe oryzae 70-15

Summary

MGG_05651 (MoCKB1) encodes a casein kinase II beta regulatory subunit, a component of the casein kinase II complex. The gene product exhibits protein serine/threonine kinase inhibitor, regulator, and activator activities. MoCKB1 is associated with appressorium formation, signal transduction, DNA damage response, cell cycle modulation, and regulation of transcription by RNA polymerases I, II, and III, including positive regulation of chromatin silencing at centromeres and silent mating-type cassettes. It localizes to the nucleus, cytoplasm, mitotic spindle pole body, UTP-C complex, and casein kinase II complex. The gene is linked to blast disease in rice (Oryza sativa). Phenotypic associations include altered cell cycle progression, abnormal chromosome segregation, decreased meiotic recombination, increased thermotolerance, abnormal telomere length, decreased radiation resistance, and absent filamentous growth and budding.