CSN5 — Magnaporthe oryzae 70-15

Summary

MoCSN5 (MGG_05274) in Magnaporthe oryzae 70-15 encodes the COP9 signalosome complex subunit 5, a metallopeptidase with deNEDDylase activity that binds metal ions. This gene is associated with photomorphogenesis, circadian rhythm, cleistothecium development, protein deneddylation and neddylation, nuclear export, cell cycle modulation, hyphal growth, proteolysis, and autophagy. The encoded product localizes to the COP9 signalosome complex, cytoplasm, cytosol, and nucleus. MoCSN5 is linked to protein content and numerous phenotypes including altered shmoo formation, mating efficiency, cell cycle progression, cell death, cell size, redox state, mitochondrial and peroxisomal distribution, flocculation, and vegetative growth rate. Studies of related genes in other species connect the family to COP9 signalosome function, cell cycle regulation, and ubiquitin-proteasome pathways.