TYR1 — Magnaporthe oryzae 70-15

Summary

MGG_05276 (MoTYR1, TYR1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a prephenate dehydrogenase with NADP+ and NAD+ activity, a cytosolic enzyme in the tyrosine biosynthesis pathway. The gene is associated with a wide range of cellular and developmental processes, including abnormal cell cycle progression, bipolar budding, septum formation, and chromosome segregation. It has been linked to increased vegetative growth, sporulation efficiency, autophagy, and lifespan, as well as altered respiratory and fermentative metabolism, carbon source utilization, and decreased freeze-thaw resistance. Associations with abnormal nuclear position, nucleolar morphology, spindle morphology, RNA localization and accumulation, and peroxisomal transport have also been observed. Studies of related genes in other species connect the family to nitrogen source utilization, endocytosis, and starvation resistance.