LEU1 — Magnaporthe oryzae 70-15

Summary

MGG_05223 (MoLEU1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a 3-isopropylmalate dehydrogenase (EC 1.1.1.85) with an isopropylmalate dehydrogenase domain. The gene is associated with L-leucine anabolism, appressorium formation, morphogenesis, the glyoxylate cycle, signal transduction, protein synthesis, and cellular localisation, and its product localises to the cytosol. MoLEU1 has been linked to blast on both rice and barley. Phenotypic associations link the gene to altered cell cycle progression, cytokinesis, aneuploidy, invasive and pseudohyphal growth, nutrient uptake, respiratory metabolism, autophagy, and prion formation, among many other cellular and metabolic traits. Studies of related genes in other species connect the family to colony appearance.