PTC1 — Magnaporthe oryzae 70-15

Summary

MGG_05207 (MoPTC1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a protein phosphatase 2C (PP2C) with MAP kinase serine/threonine phosphatase activity, adenylyl cyclase activity, and protein serine/threonine phosphatase activity. The gene is associated with downregulation of the MAPK cascade, cAMP anabolism, appressorium formation, the unfolded protein response, dephosphorylation, cellular osmotic response, protein phosphorylation, intracellular signal transduction, fungal-type cell wall organization, sporulation, hyphal growth, signal transduction, homeostasis, and the cell cycle. The encoded protein localises to the cytoplasm, cytosol, and nucleus. MoPTC1 is associated with blast disease in rice and barley. Studies of related genes in other species connect the family to loss of pathogenicity.