IFA38 — Magnaporthe oryzae 70-15

Summary

MGG_05096 (MoIFA38) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330), a member of the short-chain dehydrogenase/reductase (SDR) family with a NAD(P)-binding domain. The protein localises to the endoplasmic reticulum membrane and is associated with very-long-chain fatty acid elongation, sphingolipid biosynthesis, secondary metabolite production, penetration peg formation, and host invasion. The gene is linked to numerous phenotypes including absent spore germination, arrested vegetative growth, abnormal cytokinesis, decreased mating efficiency, altered endomembrane and Golgi morphology, reduced acquired thermotolerance, and increased telomere length. Studies of related genes in other species connect the family to carbon source utilisation and chromosome maintenance. MoIFA38 has been linked to blast disease in rice and barley.