PMC1 — Magnaporthe oryzae 70-15

Summary

MoPMC1 (MGG_04890) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a P-type ATPase of the IIB subfamily with cation-transporter domains. The enzyme exhibits P-type potassium:proton transporter activity, K+-transporting ATPase activity, and additional cation transporter activities including sodium, manganese, and calcium transport. It is associated with conidium germination, ion membrane transport, potassium and sodium ion export, cellular ion homeostasis, and response to unfolded protein. The protein localizes to the plasma membrane, vacuolar membrane, Golgi membrane, ER membrane, and nuclear envelope. Phenotypic associations include abnormal Golgi distribution and morphology, absent spore germination, decreased necrotic cell death, increased ionic stress resistance, and defects in endocytosis, vacuolar transport, and mitophagy. Related genes in other species link the family to calcium sensitivity and reduced virulence.