CDCA — Magnaporthe oryzae 70-15

Summary

MoCDCA (MGG_04637) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a dual-specificity phosphatase with protein tyrosine/serine/threonine phosphatase activity (EC 3.1.3.48), containing DSPn, CDC14_C, and Tyr_Pase_cat domains. The gene is associated with regulation of cell septum assembly, cytokinesis, mitotic spindle elongation, exit from mitosis, and appressorium formation. It is linked to glycogen metabolism, rDNA packaging, meiotic spindle breakdown, and autophagy of mitochondria. Localisation evidence connects the product to the RENT complex, spindle pole body, actomyosin contractile ring, and primary cell septum. Phenotypic associations include temperature-sensitive growth, absent or decreased septum formation, altered cell cycle progression (G1, G2, anaphase, telophase), increased polyploidy, delayed chromosome segregation, and absent mating efficiency. Studies of related genes in other species link the family to mitotic exit and cytokinesis regulation.