PER1 — Magnaporthe oryzae 70-15

Summary

MoPER1 (MGG_04527) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a Per1-like family protein with esterase activity. The gene is associated with appressorium formation, osmotic response, GPI anchor anabolism, and biological regulation, and its product localises to the fungal-type vacuole membrane and ER membrane. MoPER1 is linked to blast in rice and barley. Phenotypic associations include abnormal autophagy, mitophagy, pexophagy, and micronucleophagy; absent or altered vacuolar transport, protein secretion, budding, and small molecule transport; increased vegetative growth, sporulation efficiency, and respiratory growth; decreased nutrient uptake, freeze-thaw resistance, and pheromone production; and abnormal cell cycle progression, meiosis, Golgi distribution, and subcellular morphology. Studies of related genes in other species connect the family to abnormal protein transport, cell shape, budding pattern, and decreased stress resistance.