CSE1 — Magnaporthe oryzae 70-15

Summary

MoCSE1 (MGG_03994) on chromosome 6 of Magnaporthe oryzae 70-15 encodes an importin alpha re-exporter, a protein with XPO2 and importin-beta N-terminal domains that acts as a nuclear export signal (NES) receptor and binds small GTPases and GTP. The gene is associated with nuclear import and export, snRNA import into the nucleus, autophagy, and protein-nucleus export. It has been linked to abnormal cell cycle progression through G1/S and S phases, decreased autophagy and nucleophagy, abnormal chromosome segregation, increased hyperosmotic stress resistance, decreased viability, altered cellular and bud morphology, and changes in carbon source utilization and respiratory growth. Localization evidence connects the product to the nuclear periphery, nuclear envelope, cytosol, and macromolecular complexes. Studies of related genes in other species link the family to chromosome segregation and nuclear transport functions.