URM1 — Magnaporthe oryzae 70-15

Summary

MGG_03978, designated MoURM1 (URM1) on chromosome 6 of Magnaporthe oryzae 70-15, encodes a protein with a molybdopterin synthase/thiamin S beta-grasp domain and is associated with sulfur carrier activity, protein tag, protein homodimerization activity, and metal binding. The gene is associated with tRNA thiolation, tRNA wobble uridine thiolation, tRNA wobble uridine modification, translation elongation, innate immunity, invasive growth in response to glucose limitation, cellular response to oxidative stress, detoxification, secretion, cell budding, and tRNA modification. It localizes to the cytosol and nucleus. Phenotypic associations include increased virulence, abnormal cell cycle progression, absent spore germination and filamentous growth, delayed mitophagy and pexophagy, increased ionic stress resistance, and aberrant nuclear transport, plasma membrane morphology, and vacuolar distribution. Related genes in other species link the family to oxidative stress response.