ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_03736) on chromosome 4 of Magnaporthe oryzae 70-15 encodes an ABC transporter with ATP hydrolase activity, heme binding, and transmembrane transporter activities for cadmium ions, heme, phytochelatins, and xenobiotics. The protein localises to the vacuolar membrane, plasma membrane, Golgi, and extracellular vesicles. It is associated with heme export from the vacuole, cellular detoxification of cadmium ions, glutathione transport into the vacuole, response to metals and toxic substances, host invasion, cell wall biogenesis, secondary metabolism, and siRNA-mediated post-transcriptional gene silencing. Phenotypic associations include altered vacuolar morphology, decreased hyperosmotic and hypo-osmotic stress resistance, abnormal cell cycle progression, increased pexophagy, and decreased endocytosis rate. Studies of related genes in other species link the family to oxidative stress response and leaf morphology traits.