FRDA — Magnaporthe oryzae 70-15

Summary

MoFRDA (MGG_03619) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a flavocytochrome c protein with fumarate reductase (NADH), succinate dehydrogenase (quinone), and L-lactate dehydrogenase (cytochrome) activities, along with electron transfer activity, FMN, FAD, and heme binding. It is associated with respiratory chain complex II, the mitochondrial inner membrane, and the ER membrane. The gene is linked to appressorium formation and maturation, conidiophore development, asexual reproduction, pigmentation, autolysis, cell development, TORC2 signaling, negative regulation of autophagy, UMP anabolism, fumarate and lactate metabolism, oxidative phosphorylation, and responses to reactive oxygen species and osmotic stress. Associations with turgor pressure, germination rate, and oxidative stress response have been noted, alongside phenotypes including increased cell death, decreased necrotic cell death, increased lifespan, and abnormal mitochondrial genome maintenance.