SNX4 — Magnaporthe oryzae 70-15

Summary

MGG_03638 (SNX4, also known as MoATG24 and MoSNX4) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein containing a PX domain and an AH/BAR domain superfamily, and binds phosphatidylinositol-3-phosphate and phosphoinositides. The gene is associated with autophagy, including mitophagy, ER-phagy, and the cytoplasm-to-vacuole targeting pathway, as well as endocytic recycling, protein localization to endosomes, and mitochondrial fusion and fission. It is linked to glycogenolysis, glycogen metabolism, the TCA cycle, electron transport chain, ubiquinone and CoA biosynthesis, and regulation of ATP anabolism. Associations with ferroptosis and oxidative stress response have been noted. The encoded protein localizes to endosome membranes, the pre-autophagosomal structure, mitochondria, and the cytosol. SNX4 is associated with blast disease in rice, and phenotypes linked to the gene include abnormal sporulation, decreased autophagy and pexophagy, delayed vacuolar transport, and altered adhesion and cell death.