EMG1 — Magnaporthe oryzae 70-15

Summary

MoEMG1 (MGG_03587) on chromosome 4 of Magnaporthe oryzae 70-15 encodes the essential-for-mitotic-growth 1 (EMG1/NEP1) protein, a member of the ribosomal RNA methyltransferase family with rRNA (pseudouridine) methyltransferase activity and rRNA binding. The gene is associated with ribosome biogenesis, rRNA base methylation, and processing of the SSU-rRNA transcript, as well as programmed cell death, sporulation, secretion, the MAPK cascade, pheromone response, and stomatal closure. It localises to the nucleolus, 90S preribosome, SSU processome, nucleus, and cytoplasm. Phenotypic associations include altered vegetative growth, sporulation, cell cycle progression in G1 phase, increased desiccation and hyperosmotic stress resistance, decreased pseudohyphal growth, and abnormal meiosis, nucleolar morphology, and chitin deposition. Related genes in other species link it to ribosome assembly and cell cycle control.