ACS1 — Magnaporthe oryzae 70-15

Summary

MoACS1 (MGG_03201) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein with AMP-binding and acetyl-CoA ligase domains, possessing acetate-CoA ligase and amide synthase activities (EC 6.2.1.1). The gene is associated with ethylene and penicillin anabolism, acetoin and acetate breakdown, pyruvate fermentation to acetate, acetyl-CoA anabolism, defense and immune responses, cell death, and heterotrophy. Its product localizes to the nucleolus, cytosol, and extracellular space. Phenotypic associations include abnormal carbon source utilization, decreased hypoosmotic stress resistance, absent adhesion, absent pheromone production and sensitivity, sterile phenotype, decreased fermentative growth and metabolism, abnormal spore wall formation, increased X-ray resistance, and delayed cell cycle metaphase-anaphase transition. Studies of related genes in other species link the family to protein content.