prp19 — Magnaporthe oryzae 70-15

Summary

MGG_03116 (prp19) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein with a Prp19 core domain, a U-box domain, and WD40 repeats, possessing both ubiquitin ligase activity (EC 2.3.2.27) and cis-trans proline isomerase activity. The gene is associated with mRNA splicing via the spliceosome, protein K63-linked ubiquitination, sumoylation, and DNA repair. Its product localises to the nucleus, cytoplasm, cytosol, nuclear envelope, and spliceosomal complexes. Studies of related genes in other species link the Prp19 family to the Prp19 complex. Transferred evidence from sequence similarity also connects the family to germination rate and oxidative stress response.