PTC5 — Magnaporthe oryzae 70-15

Summary

MGG_03154 (MoPTC5) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a PPM-type phosphatase domain-containing protein with PP2C family features, possessing pyruvate dehydrogenase (lipoamide) phosphatase, MAP kinase serine/threonine phosphatase, and protein serine/threonine phosphatase activities. The gene is associated with appressorium formation, sporulation, hyphal growth, the unfolded protein response, cellular osmotic response, signal transduction, cell cycle regulation, and the pyruvate dehydrogenase pathway. It is linked to blast disease on rice and barley. Phenotypic associations include increased ionic stress resistance, increased autophagy and mitophagy, decreased sporulation and filamentous growth, abnormal vegetative growth and colony appearance, decreased alkaline pH resistance, and G1 phase cell cycle arrest. The protein localises to mitochondria, the mitochondrial lumen and envelope, peroxisomes, the cytosol, and the nucleus.