ALO1 — Magnaporthe oryzae 70-15

Summary

MGG_02689 (ALO1, MoALO1) in Magnaporthe oryzae 70-15 on chromosome 7 encodes a sugar lactone oxidase with L-gulonolactone oxidase, L-galactonolactone oxidase, and D-arabinono-1,4-lactone oxidase activities, binding FAD. The gene is associated with conidiophore development, appressorium formation, filamentous growth in response to starvation, cellular detoxification, and the TCA cycle and fatty acid metabolism. The product localises to the mitochondrial outer membrane and plasma membrane. Phenotype associations include abnormal mitochondrial genome maintenance, distribution, and transport, aberrant cell cycle progression, increased budding, abnormal cell size, and altered chitin deposition. Studies of related genes in other species link the family to decreased oxidative stress resistance and abnormal cell cycle and chromosome maintenance.