HST1 — Magnaporthe oryzae 70-15

Summary

MGG_02488 (MoHST1) encodes an NAD-dependent histone deacetylase of the sirtuin family, with activity toward histone H3K4, H3K9, H3K14 and H4K16, and functions as a transcription corepressor. The gene is associated with suppression of host immune responses, adhesion to host, regulation of fungal-type cell wall biogenesis, phenotypic switching, and epigenetic regulation of gene expression. It is linked to heterochromatin assembly at centromeres, telomeres, rDNA and mating-type regions, and localizes to the nuclear lumen and the SET3C complex. Associations include increased virulence, altered biofilm formation, flocculation, sporulation, oxidative stress resistance, and cell cycle progression. Related genes in other species are linked to oxidative stress response.