PRP2 — Magnaporthe oryzae 70-15

Summary

MoPRP2 (MGG_02518) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a protein with DEAD-box helicase OB fold, helicase-associated domain, DNA/RNA helicase DEAH conserved sequence, helicase ATP-binding domain, helicase C-terminal domain, and P-loop NTPase domain. The product has 3'-5' RNA helicase activity, ATP binding and hydrolysis, mRNA binding, and is a component of the spliceosome, localising to the U2-type activated spliceosome and catalytic step 2 spliceosome, and is associated with mRNA splicing, spliceosome disassembly, and ribosome biogenesis. MoPRP2 is linked to asexual and sexual reproduction, hyphal growth, pigmentation, chitin anabolism, and the mitotic cell cycle. It has been connected to blast disease in rice (Oryza sativa). Phenotypic associations include abnormal carbon source utilisation, altered cell cycle progression, delayed chromosome segregation, increased mating efficiency, and defects in nuclear fusion and mating-type switching.