AOS1 — Magnaporthe oryzae 70-15

Summary

MGG_01669 (MoAOS1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a protein with a UBQ/SUMO-activ_enz_E1-like domain and ubiquitin-activating enzyme activity, and is associated with RUB1 activating enzyme activity, SMT3 activating enzyme activity, ATP binding, ATP hydrolase activity, and metal binding. The gene is associated with protein neddylation, sumoylation, protein ubiquitination, ubiquitin-dependent proteolysis, mitotic chromosome condensation, DNA damage response, DNA repair, cell cycle, and appressorium formation. It has been linked to delayed exponential-phase growth, abnormal nuclear export, decreased nuclear import, delayed cell cycle progression through metaphase and G2/M phase, increased aneuploidy, increased hyperosmotic stress resistance, increased viability, increased telomere length, and increased transposable element transposition. The protein localises to the cytoplasm, cytosol, nucleus, and the SAE complex. Studies of related genes in other species link the family to increased innate thermotolerance.