PHM8 — Magnaporthe oryzae 70-15

Summary

MGG_01783 (MoPHM8, also known as MoSDT1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a pyrimidine 5'-nucleotidase with nucleotidase and 5' nucleotidase activity, belonging to the HAD-superfamily hydrolase subfamily IA. The gene is associated with defense response, cell death, protein phosphorylation, nucleotide breakdown, pyrimidine base metabolism, and raffinose anabolism. Its product localizes to both the cytosol and nucleus. MoPHM8 is associated with numerous cellular and developmental phenotypes, including abnormal cell cycle progression, budding, cell size, and morphology, as well as decreased sporulation, viability, and filamentous growth, and increased chitin deposition. Studies of related genes in other species connect the family to oxidative stress response, phosphate content, and altered carbon and nitrogen source utilization.