ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_01674) on chromosome 2 of Magnaporthe oryzae 70-15 encodes an ABC transporter with ATP hydrolase activity, haem-transporting ATPase activity, and cadmium ion transmembrane transporter activity, and belongs to the ABC1 transmembrane domain superfamily. The gene is associated with haem export from the vacuole to the cytoplasm, cellular detoxification of cadmium ions, glutathione and phytochelatin import into the vacuole, and xenobiotic detoxification via transmembrane export across the plasma membrane. It is linked to host invasion, interaction with the host, filamentous growth in response to starvation, cell wall biogenesis, secondary metabolism, and siRNA-mediated post-transcriptional gene silencing. The product localises to the fungal-type vacuole membrane, plasma membrane, Golgi complex, extracellular vesicles, and cytoplasm. Phenotypic associations include altered vacuolar morphology, increased pexophagy, decreased endocytosis, abnormal cell cycle progression, and altered stress resistance.