CAP1 — Magnaporthe oryzae 70-15

Summary

MoCAP1 (MGG_01722) on chromosome 2 of Magnaporthe oryzae 70-15 encodes an adenylyl cyclase-associated protein (CAP) that binds adenylyl cyclase and actin. The gene is associated with appressorium formation, host invasion, invasive growth, conidia formation, hyphal growth, melanin anabolism, secretion, endocytosis, vacuolar transport, actin filament organization, and the glucose-sensing PKA pathway. It is linked to regulation of growth, downregulation of cell growth, and downregulation of conjugation with cellular fusion. The protein localizes to the growing cell tip, division septum, cross wall, and cytoplasm. Phenotypic associations include abnormal filamentous growth, absent spore germination, sterile, abnormal chitin deposition, abnormal autophagy, increased and decreased pexophagy, absent and increased pheromone sensitivity, decreased pheromone production, and increased cell cycle progression in G1 phase. Studies of related genes in other species link the family to oxidative stress response and acid sensitivity.