DBP2 — Magnaporthe oryzae 70-15

Summary

MGG_01583 (DBP2, also known as PRP28) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a DEAD-box RNA helicase with ATP hydrolase and nucleic acid binding activities, including mRNA binding and RNA helicase activity. It is associated with first spliceosomal transesterification activity and localises to the U5 snRNP, catalytic step 2 spliceosome, cytoplasm and nucleus. The gene is linked to mRNA 5'-splice site recognition, RNA splicing, mRNA processing, digestion, sexual reproduction and mating. Phenotypic associations include abnormal mitotic recombination, decreased mating type switching, absent sporulation efficiency, altered cell cycle progression (including G1/S and G2/M phase transitions), delayed vegetative and exponential growth, increased thermotolerance and gamma ray resistance, and altered carbon source utilisation and fermentative growth. Studies of related genes in other species link the family to oxidative stress response and unaffected pathogenicity.