LUA — Magnaporthe oryzae 70-15

Summary

MGG_01553 (MoLUA) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a protein with domains including 3-isopropylmalate dehydratase large and small subunits, and is annotated with 3-isopropylmalate dehydratase and homoaconitate hydratase activities, 4Fe-4S cluster binding, and metal binding. The gene is associated with L-leucine biosynthesis, appressorium formation, morphogenesis, protein synthesis, and signal transduction, and its product localises to the isopropylmalate isomerase complex, mitochondrial lumen, and cytosol. MoLUA is linked to blast disease on rice and barley, and to numerous phenotypes including decreased sporulation, abnormal colony appearance, altered stress resistances (e.g., decreased hyperosmotic and acid pH resistance, increased oxidative stress resistance), auxotrophy, and changes in telomere length, mutation frequency, and replicative lifespan. Related genes in other species link the family to homoaconitate hydratase activity (EC 4.2.1.36) and to associations with Zea mays, Triticum aestivum, and fusarium head blight.