CDC5 — Magnaporthe oryzae 70-15

Summary

MGG_01426 (CDC5/CEF1) in Magnaporthe oryzae 70-15 encodes a protein with a Myb/SANT DNA-binding domain and belongs to the CDC5L/Cef1 family. The product is associated with mRNA splicing via the spliceosome, cell division, cell cycle, and filamentous growth. It localizes to the nucleus, cytoplasm, cytosol, spliceosome, and Prp19 complex. The gene is linked to numerous cellular phenotypes including abnormal spindle and cytoskeleton morphology, cell cycle arrest at metaphase and G2/M transition, delayed G1/S phase progression, increased nucleus size, abnormal meiosis and sporulation, decreased X-ray resistance, altered nitrogen utilization, and increased biofilm formation. It is also associated with blast disease in rice. Studies of related genes in other species link the family to spliceosome components CWC15, CWC22, and SMX proteins.