VPS17 — Magnaporthe oryzae 70-15

Summary

MoVPS17 (MGG_01434) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a retromer complex component with a Vps17_PX domain that binds phosphatidylinositol-3-phosphate. The gene is associated with retrograde transport from endosome to Golgi, intracellular protein transport, endocytosis, and FSM assembly. Its product localises to the SNX-BAR dimer, retromer complex, endosome, cytosol, and nucleus. MoVPS17 is associated with autophagy, pexophagy, mitophagy, sporulation efficiency, meiosis, cell cycle progression, bipolar budding, pseudohyphal growth, mating response, vacuolar transport, protein secretion, cold sensitivity, peroxisomal morphology, nitrogen source utilisation, and vegetative growth. The gene is also linked to Hordeum vulgare and Oryza sativa. Studies of related genes in other species connect the family to acid sensitivity and oxidative stress response.