CHO1 — Magnaporthe oryzae 70-15

Summary

MoCHO1 (MGG_01295) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a phospholipid methyltransferase (EC 2.1.1.71) of the PEMT/MFAP family, localized to the ER and mitochondrial membranes. The gene is associated with phosphatidylcholine anabolism via the Kennedy pathway, methionine metabolism, methylation, autophagy, defense response, and cleistothecium development. Phenotypic associations include delayed vegetative growth, decreased spore germination, increased apoptosis, delayed autophagy, decreased nucleophagy and ribophagy, increased polyploidy and aneuploidy, abnormal colony shape, and decreased meiosis and nuclear fusion during mating. Related genes in other species are linked to copper sensitivity and oxidative stress response.