CLM2 — Magnaporthe oryzae 70-15

Summary

MoCLM2 (MGG_01138) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a cytochrome P450 2C31 protein belonging to the Cyt_P450_E_grp-I family. The gene product exhibits tryptamine 4-monooxygenase activity, oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen, monooxygenase activity, heme binding, and iron binding. It is associated with psilocybin biosynthetic process, demethylation, mitophagy, sporulation, hyphal growth, and ergosterol anabolism, and localises to the membrane. Phenotypic associations include decreased micronucleophagy and nucleophagy, abnormal plasma membrane morphology, increased cell death, decreased invasive growth, arrested vegetative and exponential-phase growth, increased lifespan, decreased nutrient uptake, and abnormal cell cycle progression through G2/M and S phases. Studies of related genes in other species link the family to ergosterol biosynthesis and sterol 14α-demethylase activity.