CLR3 — Magnaporthe oryzae 70-15

Summary

MoCLR3 (MGG_01076) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a histone deacetylase with activity toward multiple histone residues, including histone H3-K9, H3-K14, H4-K12, H4-K16, and H4-K5/K8, and is classified as EC 3.5.1.98. The protein contains a histone deacetylase domain and an Arb2 domain, and it localizes to HDAC complexes such as HDA1, Rpd3S, SET3C, and heterochromatin islands. MoCLR3 is associated with appressorium-mediated host invasion, appressorium formation, pigmentation, asexual sporulation, and epigenetic regulation of gene expression, including heterochromatin island assembly, centromeric silencing, and rDNA heterochromatin assembly. It is also linked to filamentous growth in response to pH, phenotypic switching, and cellular response to basic pH. Phenotypic associations include altered mating-type switching, sporulation rate, nutrient uptake, carbon source utilization, and cell cycle progression.