NRF1 — Magnaporthe oryzae 70-15

Summary

MGG_01006 (MoNRF1, also known as MoVTC1) encodes vacuolar transporter chaperone 1, a protein with polyphosphate kinase and GTPase regulator activities that binds ATP and mRNA. In Magnaporthe oryzae, it is associated with vacuolar transport, exocytosis, homotypic vacuole fusion, microautophagy, defense response, hormone response and anabolism, polyphosphate import into the vacuole, and energy reserve metabolism. The protein localizes to the VTC complex, vacuolar membrane, nuclear membrane, ER, and cell division site. Phenotypic associations include abnormal vacuolar, Golgi, and ER distribution; delayed vacuolar transport, endocytosis, and sporulation; increased necrotic cell death; premature cell cycle progression through G2/M; and altered chemical compound accumulation and transport. Studies of related genes in other species link the family to phosphate content and zinc sensitivity.