APR1 — Magnaporthe oryzae 70-15

Summary

MoAPR1 (MGG_00922) on chromosome 5 of Magnaporthe oryzae 70-15 encodes an aspartic endopeptidase (EC 3.4.23.25) belonging to the aspartic peptidase A1 family, with oligosaccharide and disordered domain specific binding activities. The gene is associated with autophagy, pexophagy, macroautophagy, microautophagy, and the cytoplasm-to-vacuole targeting pathway, as well as proteolysis, endocytosis, and cellular homeostasis. It localizes to the vacuolar lumen, fungal-type vacuole, extracellular region, and macromolecular complexes. Phenotypic associations link MoAPR1 to abnormal sporulation efficiency, delayed autophagy and pexophagy, arrested cell cycle progression, abnormal nuclear fusion during mating, and altered vesicle distribution, vacuolar transport, and plasma membrane morphology. The gene is also connected to blast disease in rice and barley, and related genes in other species link the family to vacuolar proteolysis and autophagy regulation.