CLM2 — Magnaporthe oryzae 70-15

Summary

MoCLM2 (MGG_00832) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a cytochrome P450 with heme and iron binding, oxidoreductase and redox activities. The gene is associated with demethylation, small molecule biosynthesis, mitophagy, sporulation, hyphal growth, and ergosterol anabolism, and its product localises to membranes. Annotated associations link MoCLM2 to abnormal plasma membrane and endoplasmic reticulum morphology, increased cell death and apoptosis, decreased mitophagy, arrested vegetative growth, reduced invasive growth, altered carbon and iron utilisation, increased biofilm formation, and decreased resistance to chemicals and alkaline pH. The gene is also connected to abnormal actin cytoskeleton, budding pattern, cell shape and size, lipid particle morphology, and increased fermentative metabolism. Related genes in other species link the cytochrome P450 family to sterol 14α-demethylase activity in ergosterol synthesis.