GGA1 — Magnaporthe oryzae 70-15

Summary

MGG_00852 (MoGGA1) on chromosome 5 of Magnaporthe oryzae 70-15 encodes an ADP-ribosylation factor-binding protein GGA1, a member of the GGA family with VHS, GAT and GAE domains. The product binds phosphatidylinositol-3-phosphate, phosphoinositides, ubiquitin and zinc. It is associated with Golgi localisation, trans-Golgi network to endosome transport, retrograde endosome-to-Golgi transport, vacuolar protein sorting, protein-vacuolar targeting during ubiquitin-dependent breakdown via the MVB pathway, hyphal growth and host invasion. The protein localises to the ESCRT-0 complex, trans-Golgi network membrane, endosome membrane, Golgi complex, cytosol and nucleus. Associations with abnormal spore germination, Golgi morphology, endocytosis, protein transport, cell fusion, meiosis, budding, shmoo formation, micronucleophagy, cell death and ionic stress resistance have been noted, along with links to barley and rice blast. Studies of related genes in other species connect the family to loss of pathogenicity.