CKS1 — Magnaporthe oryzae 70-15

Summary

MGG_00682 (MoCKS1, also known as CKS1 or SUC1) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a cyclin-dependent kinase regulatory subunit, a member of the cyclin-dependent kinase regulator subunit superfamily. The product possesses cyclin-dependent protein serine/threonine kinase activator and regulator activities, protein kinase activator activity, and binds protein kinases, histones, ubiquitin, and zinc. MoCKS1 is associated with cell cycle control and modulation, mitotic cell cycle modulation, hyphal growth, morphogenesis, pigmentation, sexual reproduction, programmed cell death, signaling, nuclear import, and the metabolic burst. It localises to the nucleus, cytosol, CDK holoenzyme, and SCF complex. The gene is linked to numerous cell cycle phenotypes including altered G2/M phase transition, chromosome segregation, sporulation, mating-type switching, and adhesion. Studies of related genes in other species connect the family to cell cycle regulation and leaf size.