LEU3 — Magnaporthe oryzae 70-15

Summary

MoLEU3 (MGG_00672) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a Zn2Cys6 DNA-binding transcription factor with DNA-binding transcription activator activity and RNA polymerase II-specific transcription factor activity. The gene is associated with regulation of cellular response to iron ion starvation, riboflavin transport, cellular response to basic pH, cellular iron ion homeostasis, interaction with host, upregulation of filamentous growth in response to biotic stimulus, morphogenesis, filamentous growth, and DNA repair. It localises to both cytoplasm and nucleus. Phenotypic associations include abnormal mitochondrial transport, absent meiosis, increased X-ray resistance, decreased pexophagy and mitophagy, increased flocculation, altered carbon source utilisation, increased silencing, decreased meiotic and mitotic recombination, arrested cell cycle progression, abnormal nuclear morphology, absent sporulation, and increased resistance to chemicals and enzymatic treatment. Studies of related genes in other species link the family to reduced virulence and altered stress resistance.