TPC1 — Magnaporthe oryzae 70-15

Summary

MGG_00489 (TPC1, MoTPC1) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a mitochondrial carrier family protein with thiamin permease and thiamine diphosphate transporter activities. The gene is associated with thiamine pyrophosphate transport, calcium signaling, morphogenesis, lipid metabolism, autophagy, host invasion, and localization to the mitochondrial inner membrane. It is also linked to responses to cold and salicylate. Studies of related genes in other species connect the family to reduced virulence, decreased vegetative growth, altered vacuolar morphology, increased chronological lifespan, and decreased competitive fitness, as well as associations with invasive pulmonary aspergillosis.