HSE1 — Magnaporthe oryzae 70-15

Summary

MGG_00455 (HSE1, MoHSE1) in Magnaporthe oryzae 70-15 on chromosome 5 encodes a protein containing GAT, VHS, SH3, and ubiquitin-interacting motif (UIM) domains, with phosphoinositide and ubiquitin binding activities. It is associated with the ESCRT-0 complex and endosome membrane, and linked to regulation of autophagy, ER-phagy, appressorium formation, protein vacuolar targeting via the MVB pathway, deubiquitination, and homeostasis. The gene is associated with abnormal spore germination, increased vegetative growth, abnormal cell wall morphology, increased lifespan, increased osmotic stress resistance, and changes in respiratory and fermentative metabolism, as well as absent endocytosis and vacuolar transport. Studies of related genes in other species link the HSE1 family to abnormal budding, abnormal cellular morphology, and decreased chitin deposition.