CDC25 — Magnaporthe oryzae 70-15

Summary

MGG_00371 (CDC25) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a class E vacuolar protein-sorting machinery protein HSE1, a member of the Ras guanine nucleotide exchange factor (RasGEF) family that contains SH3 and WW domains. The gene is associated with Ras protein signal transduction, positive regulation of the pheromone response MAPK cascade, and adenylate cyclase-activating GPCR signaling. It is linked to appressorium formation, hyphal growth, filamentous growth of a population of unicellular organisms in response to starvation and biotic stimulus, traversing the start control point of the mitotic cell cycle, and upregulation of exit from mitosis. Additional associations include protein localization to the mitotic spindle, cellular response to glucose stimulus and starvation, conjugation with cellular fusion, establishment or maintenance of cell polarity, and vesicle transport. The encoded product localizes to the endosome membrane, plasma membrane, cytoplasm, cytosol, cellular bud, and mating projection actin fusion focus.