TFB2 — Magnaporthe oryzae 70-15

Summary

MGG_00397 (TFB2, MoTFB2) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a protein containing TFIIH_p52/Tfb2 and Tfb2_C domains, with ATPase activator activity, general transcription factor activity, and double-stranded DNA binding. The gene is associated with transcription initiation from RNA polymerase II promoters, nucleotide excision repair, and hyphal growth, and localizes to the cytoplasm, holo TFIIH complex, and NEF3 complex. Associations include decreased resistance to ionizing radiation and X-rays, increased UV resistance, abnormal cell cycle progression (G1 delay, G2/M arrest), absent autophagy and vegetative growth, increased pseudohyphal and respiratory growth, altered nutrient utilization, and abnormal sporulation, meiosis, and silencing. Studies of related genes in other species link the family to core TFIIH complex function and DNA repair.