ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_00239) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a multidrug resistance protein 1, an ABC-type oligopeptide transporter with ATP-coupled transmembrane transporter activity and ATP hydrolase activity. The gene is associated with host invasion, invasive growth, morphogenesis, cell wall biogenesis, secondary metabolism, autophagy, signal transduction, and regulation of cell growth. It is linked to siRNA-mediated post-transcriptional gene silencing, transposition, retrotransposition, and translation elongation. The product localises to the mitochondrial inner membrane, plasmalemma, and membrane. Phenotypic associations include abnormal colony colour, decreased hyperosmotic and hypo-osmotic stress resistance, altered vacuolar morphology and distribution, increased pexophagy, abnormal cell cycle progression, decreased endocytosis, and altered protein/peptide accumulation. Studies of related genes in other species connect the family to oxidative stress response.