BNI1 — Magnaporthe oryzae 70-15

Summary

MoBNI1 (MGG_17697) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a cytokinesis protein sepA, a formin family member containing FH2, FH3, DAD, and GTPase-binding domains. The product binds actin, F-actin, small GTPases, SH3 domains, and F-BAR domains. MoBNI1 is associated with actin nucleation, filament bundle assembly and organization, barbed-end capping, depolymerization, and cortical patch localization. It is linked to mitotic actomyosin contractile ring assembly and protein localization to that ring, cytogamy, cell polarity establishment and maintenance, bud site selection, cell shape regulation, and appressorium formation. The protein localizes to the actin cytoskeleton, actomyosin contractile ring, Spitzenkörper, septin rings, and mating projection structures. Studies of related genes in other species link the family to polarized growth and cytokinesis.