SDH1 — Magnaporthe oryzae 70-15

Summary

MoSDH1 (MGG_00168) on chromosome 5 of Magnaporthe oryzae 70-15 encodes the flavoprotein subunit of succinate dehydrogenase (complex II), an enzyme with succinate dehydrogenase (quinone) and electron transfer activities that binds FAD. It is associated with the TCA cycle, oxidative phosphorylation from succinate to ubiquinone, and melanin biosynthesis, and localises to the mitochondrial inner membrane as part of respiratory chain complex II. The gene has been linked to numerous phenotypes including altered vegetative growth, respiratory metabolism, cell cycle progression, stress resistance (alkaline pH, acid pH, ionic stress, gamma rays, freeze-thaw), mitophagy, mitochondrial genome maintenance, flocculation, protein secretion, carbon source utilisation, and competitive fitness. Related genes in other species connect the family to oxidative stress response.