ARG4 — Magnaporthe oryzae 70-15

Summary

MoARG4 (MGG_17278) on chromosome 4 of Magnaporthe oryzae 70-15 encodes an argininosuccinate lyase (EC 4.3.2.1), a cytosolic enzyme of the fumarate lyase family that catalyses a step in the urea cycle and arginine biosynthesis. The gene is associated with pigmentation, sexual reproduction, hyphal growth, and protein synthesis. It has been linked to numerous phenotypes including abnormal colony and mitochondrial morphology, decreased sporulation and biofilm formation, altered stress resistance, increased replicative and chronological lifespan, and changes in mitophagy, pexophagy, and reticulophagy. Associations also include abnormal mitochondrial genome maintenance, increased mitotic recombination, decreased silencing, and altered pseudohyphal growth. Studies of related genes in other species connect the family to nitrogen source utilisation, auxotrophy, endocytosis, vacuolar morphology, and increased transposable element transposition.