tlh1 — Magnaporthe oryzae 70-15

Summary

MGG_16993 (tlh1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a DEAD/DEAH-box helicase with four-way junction helicase activity, 3′-5′ DNA helicase activity, RNA helicase activity, nucleic acid binding, RNA binding, ATP hydrolase activity, DNA binding, zinc binding, and ATP binding (EC 5.6.2.4). The gene is associated with mitochondrial mRNA processing, resolution of mitotic recombination intermediates, rDNA maintenance, DNA double-strand break processing, mitotic recombination-dependent replication fork processing, recombinational repair, UVER, digestion, intra-S DNA damage checkpoint, telomere maintenance via recombination, replication fork processing, sexual reproduction, DNA damage tolerance, RNA splicing, regulation of translation, HDR, DNA recombination, and mRNA processing. The product localises to the RecQ helicase-Topo III complex, nuclear chromosome, chromosome, telomeric repeat region, nuclear replication fork, site of DSB, mitochondrial lumen, nucleolus, mitochondria, and cytoplasm. Related genes in other species link the family to RNA splicing and mitochondrial gene expression, and sequence similarity also connects tlh1 to C2H2-type zinc-finger domains.