tlh1 — Magnaporthe oryzae 70-15

Summary

MGG_16579 (tlh1) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a DEAD/DEAH-box helicase with ATP-dependent four-way junction, 3'-5' DNA, and RNA helicase activities (EC 5.6.2.4). The gene is associated with mitochondrial mRNA processing, resolution of mitotic recombination intermediates, rDNA maintenance, DNA double-strand break processing, recombinational repair, replication fork processing, telomere maintenance via recombination, intra-S DNA damage checkpoint, and sexual reproduction. The encoded protein localises to the RecQ helicase-Topo III complex, nuclear chromosome, telomeric repeat region, replication fork, site of double-strand breaks, mitochondrial lumen, nucleolus, and cytoplasm. Studies of related genes in other species link the family to RNA splicing and translation regulation.