ARP1 — Magnaporthe oryzae 70-15

Summary

MoARP1 (MGG_16793) on chromosome 3 of Magnaporthe oryzae 70-15 encodes an actin-like protein with ATP binding and hydrolase activity, and it is a structural constituent of the cytoskeleton. The gene is associated with pigmentation and melanin anabolism, and its product localises to the actin cytoskeleton, dynactin complex, hyphal tip, and sites of polarised growth. MoARP1 is linked to numerous cellular processes including cell cycle progression, chromosome segregation, nuclear transport, mating projection and shmoo formation, septum formation, filamentous growth, and chitin deposition. It has also been associated with abnormal lifespan, decreased necrotic cell death, and increased mutation frequency. Studies of related genes in other species link the family to respiratory growth and acid sensitivity.