DLH1 — Magnaporthe oryzae 70-15

Summary

MoDLH1 (MGG_15576) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a protein with RecA-family domains, ATPase activity, single- and double-stranded DNA binding, and Sae3-Mei5 complex binding. The gene is associated with meiotic and mitotic recombination processes including strand invasion, heteroduplex formation, joint molecule formation, gene conversion, double-strand break repair, and telomere maintenance via recombination. It is linked to mating-type switching, post-transcriptional gene silencing, immune response, and mitochondrial DNA repair. Phenotypic associations include absent sporulation efficiency, abnormal spore germination, delayed chromosome segregation, altered cell cycle progression, and loss of X-ray resistance and mitotic recombination. The protein localises to the nucleus, chromatin, condensed nuclear chromosomes, mitochondrial chromosomes, centromere complexes, and sites of double-strand breaks. Related genes in other species connect this gene to meiotic recombination and DNA repair pathways.